Manifold for Charity

We help protect people from malaria.

Incubate longtermist nonprofits by connecting founders with ideas, funding, and mentorship.

We search for the charities that save or improve lives the most per dollar.

The Long-Term Future Fund aims to improve the long-term trajectory of civilization by making grants that address global catastrophic risks.

Faunalytics conducts research and shares knowledge to help advocates help animals effectively.

Amplify Haskell’s impact on humanity.

We shape technology for public benefit by advancing sciences of connection and integration. Our goal is a world where the systems that surround us benefit us all.

Send money directly to people living in poverty.

Accelerating the development of each vaccine by even a couple of days via COVID-19 human challenge trials could save thousands of lives.

Cavendish Labs is a longtermist research institute focused on AI alignment and pandemic prevention.

The ACLU works in the courts, legislatures, and communities to defend and preserve the individual rights and liberties guaranteed to all people in this country by the Constitution and laws of the United States.

AI Impacts answers decision-relevant questions about the future of artificial intelligence.

Feeding everyone no matter what.

Align future machine learning systems with human interests.

The Animal Welfare Fund aims to effectively improve the well-being of nonhuman animals.

Balsa Research identifies the most important policy changes America should make, and makes them happen.

Offering child care and educational services for the children of New York’s backstretch workers.

The California Renters Legal Advocacy and Education Fund’s core mission is to make lasting impacts to improve the affordability and accessibility of housing to current and future Californians, especially low- and moderate-income people and communities of color.

Camfed supports girls to learn, thrive and lead change.

Charity Entrepreneurship launches high-impact nonprofits by connecting entrepreneurs with effective ideas, training, and funding.

For over 70 years, we've led the world by making life-changing breakthroughs in cancer research and patient care, providing the most advanced treatments available.

Direct Relief is a humanitarian aid organization, active in all 50 states and more than 80 countries, with a mission to improve the health and lives of people affected by poverty or emergencies – without regard to politics, religion, or ability to pay.

We provide independent, impartial medical humanitarian assistance to the people who need it most.

EWG empowers you with breakthrough research to make informed choices and live a healthy life in a healthy environment.

The Effective Altruism Infrastructure Fund aims to increase the impact of projects that use the principles of effective altruism.

The leading nonprofit defending digital privacy, free speech, and innovation.

FYXX Foundation: wildlife population management, without killing.

Fish Welfare Initiative's mission is to improve the welfare of fish as much as possible, focusing specifically on farmed fish.

Foresight Institute supports the beneficial development of high-impact technology to make great futures more likely.

The Climate Change Fund aims to sustainably reach net-zero emissions globally, while still allowing growth to free millions from energy poverty.

The Patient Philanthropy Project aims to safeguard and benefit the long-term future of humanity

Tackling the vast global inequalities in health, wealth and opportunity

The Free Software Foundation (FSF) is a nonprofit with a worldwide mission to promote computer user freedom.

Grand Teton National Park Foundation initiates improvements, critical research, and projects that help better connect visitors to the park

The Global Health and Development Fund aims to improve people's lives, typically in the poorest regions of the world where the need for healthcare and economic empowerment is greatest.

At GFI, we’re building a world where alternative proteins are no longer alternative.

Advancing research to enhance the health and soundness of horses.

We rigorously examine charities based on subjective wellbeing

We envision a world where no one is deprived of the opportunity to live a healthy life – and reach their true potential.

Helping Shepherds of Every Color Rescue is an all volunteer German Shepherd rescue group based in Montgomery, AL.

Providing Universal Access to All Knowledge

Kiva Microfunds seeks to provide loans to those in need by crowdsourcing funds.

The Machine Intelligence Research Institute does foundational mathematical research to ensure smarter-than-human AI has a positive impact

MSI Reproductive Choices provides contraception and safe abortion services that enable women all over the world to choose their own futures.

We specialise in the prevention, control and treatment of malaria and other communicable diseases.

Develops and manages programs that ensure all Thoroughbred mares whose racing and breeding careers have ended are tracked and provided with care that protects them from suffering and cruelty.

Donate supplies to soldiers in Ukraine

NAACP's Legal Defense Fund is the premier legal organization fighting for racial justice.

Cash incentives to boost vaccination rates and save lives.

New Vocations focuses on the rehabilitation, retraining, and rehoming of retired racehorses.

Spiritual and welfare support for the backstretch community in New York's racetracks.

A sanctuary for retired thoroughbreds ensuring they live out their days with dignity.

The mission: to expose abuses of power and betrayals of the public trust by government, business, and other institutions, using the moral force of investigative journalism to spur reform through the sustained spotlighting of wrongdoing.

The Quantified Uncertainty Research Institute advances forecasting and epistemics to improve the long-term future of humanity.

Donate to Racket, a programming language, via the Software Freedom Conservancy which is a nonprofit organization centered around ethical technology

Rainforest Trust saves endangered wildlife and protects our planet by creating rainforest reserves through partnerships, community engagement and donor support.

Providing vital support to high-impact charities and charitable projects.

Uncovering actionable insights to make the world a better place.

SCI works with governments in sub-Saharan Africa to create or scale up programs that treat schistosomiasis and soil-transmitted helminthiasis ("deworming").

Through the decades, Save the Children has continued to work to save children’s lives, and that’s still what we do today.

Expanding humanity's moral circle.

Stable Recovery provides therapeutic programs using horses for men in recovery from addiction.

Providing mental health therapy in Africa

The Center for Election Science is a nonpartisan nonprofit dedicated to empowering voters with voting methods that strengthen democracy. We believe you deserve a vote that empowers you to impact the world you live in.

Support and fund research on how ideology and government policy contribute to scientific, technological, and social progress.

Fred Hollows Foundation focuses on preventable and treatable diseases such as cataract, trachoma and diabetic retinopathy

A nonpartisan, nonprofit organization that promotes and protects human rights globally, with a focus on closed societies.

We exist to end the abuse of animals raised for food by influencing the policies of the world’s biggest companies, demanding legislation, and empowering others to take action and leave animals off their plates

Providing financial relief and assistance to the horse racing community.

Our mission: to protect people’s health from epidemics and disasters and ensure that communities are resilient to major challenges.

A Future Where People and Nature Thrive

Shrimp Welfare Project aims to improve the lives of billions of farmed shrimps

The Society Library works to improve humanity's relationship to information.

An alliance working to ensure a secure future for thoroughbreds after their racing careers.

The Trevor Project is the world’s largest suicide prevention and crisis intervention organization for LGBTQ (lesbian, gay, bisexual, transgender, queer, and questioning) young people.

Supporting thoroughbreds throughout and after their racing careers and those who care for them.

The foundation is dedicated to saving thoroughbred horses from possible neglect, abuse, or slaughter.

Assists United Methodists and churches to become involved globally in direct ministry to persons in need.

UNICEF USA helps save and protect the world's most vulnerable children.

By improving access to vital nutrition, everyone gets an equal chance to grow, thrive, and prosper.

We help everyone share in the sum of all knowledge.

Our mission is to understand and improve the lives of wild animals.

WCK is first to the frontlines, providing meals in response to humanitarian, climate, and community crises. We build resilient food systems with locally led solutions.

WRI is a global nonprofit organization that works with leaders in government, business and civil society to research, design, and carry out practical solutions that simultaneously improve people’s lives and ensure nature can thrive.

WWF works to sustain the natural world for the benefit of people and wildlife, collaborating with partners from local to global levels in nearly 100 countries.

YIMBY Law works to make housing in California more accessible and affordable, by enforcing state housing laws.